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u_Yfimouɂ鎕|Pbgۖ@v̌𔭕\܂B

‚܂Ă͂TRPy؁jߌ̐fÂȂтɂUPij͏IxfɂȂ܂B

ȏAX肢܂B

RDecb̎Ì

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ʓIɂ́uv⎕a̎Â͎⎕gD̎ÂsȂΊȒPɎ悤ɎvĂ܂BAۂ̎Âł͈ȉ̗̕v݂Ɋ֌WĂ܂̂Ŋ҂ɂĂ͍ĎÂ⎡Âɂ߂čȏꍇ܂B

ÂJԂ⎡ɂ͉L̓eQƉB

PD̕a͐Sg̏ԂHוȂǂɂĉe

P|PD⎕gD͓Ɨł͂Ȃ

@ʓIɎ͐΂̂悤ɍdƎvA܂gD͎̂܂̑gDxɍlĂ邽߁ASg̕ωƖڂɊ֘AƂ͍lĂȂ悤łB̂ߎ⎕gD̕a͎ȎÂSɍsΕKƍlꂪłBA⎕gDl̂\鑟̈ꕔłȏA]̉e邱Ƃ͈wIȏ펯łB

P|QD⎕ȁǏ͐S⏔̉eɂω

PjS̉e

܂ƐS̊֌Wɂ‚ċ̓IȗĂ݂܂傤B鏈usĂmoߕqɂ錃ɂ݂ɂȂ҂łXg̍ďAE悪܂܂ƏǏ͏v܂BꂪuSv̏ǏłBƋVl̓ꎕs̃P[X֌W̉PǓƂ̕sɎX邱ƂɂǏ͉Ă܂B

Qj̉e

⎕gDɉe^aC̗ƂĂ͗ǂmĂ铜Aa͂ߐtaA邢͊̑aȂǑ̕aC܂B܂a̎Âɏ\Ȍʂオ炸A|PbgDNAʂ̃oNeAoꂽߓȎf߂ʁAxK⎡Ă͂̎q{K̍ĔȂǂĂ܂B

Rjɂe

ɂω͎̖Ղɂ͂܂A𚐂ɂؗ͂̐tʂ̒ቺAgDɕzǂ̘VȂǂ̗lXȕ̕ω炵܂B̂߂ɎÊԂA҂ꂽÌʂ𓾂Ȃꍇ܂BȂƂ܂񂪁Â悤ȌԓxKvɂȂ܂B

P|SDauv̕a͐ĤׂŗǂȂ

̎ȁǗɁAÂ𐧌HHɐ؂ւ܂ƖIȏo⎕̎ȂǂȂǂ͂RTԒxʼnP܂B̊҂̏ꍇ͐ĤׂRg[邱ƂɂĖƉu͂܂AgD̃oNeA}~͂シ邽߂ɎaP܂B

ĝ͐Ĥׂɂč\Ă܂̂ŔAHJԂȂ玕OȎpȂǂsĂꎞIȏǏPɂƂǂ܂܂B܂AHAÂD̊҂񂪁uvɂȂ΍ĎÂ̂RłB

QDecb̎Ì

ecb̎Ì́uoNeAVXevƁu_[WgDJo[VXev̂QW[ɂč\Ă܂B̎Ì́uvƎaA邢͒q͉łĂʂĂ܂B

Q|PDuvCa̎Ấuovu׋ۊwIv

r錴͂Q厕Ȏ́uvƎaɂ̂łA̎łBRA҂̎rȂ߂ɂ͊ǎÂ̋ZpxコKv܂B̂߂ecb̎Â͌oɂ炸AffAÂ̊eiKŃoNeAsȂAu׋ۊwIvɂčsȂĂ܂B

Q|QDǎÂ͕ãoNeA񂪕K{

Â̂߂ɍłKvȏ͌݁A҂́uv⎕ǎƂȂĂŌ邱Ƃ̕s”\ȃoNeAɊւłBRACúuoNeAvȂΓKmŃ^C[ȎÖ@I邱Ƃ͍łBãoNeA񂪌ǂ̎Õi͐MႭȂƍl܂B

ecb͊ǎÂlԑ΃oNeA̐푈ƍlĂ܂BoNeAɑ΂ď邱ƂÂɐ邱ƂłBãoNeA͎Ðp𗧂Ă邽߂̃RAłB

j͎Ì̊Tvł̂ŐffAÉߒ͊e͂QƉB

RDoNeAZp

ecb̃oNeAZpƂ́Aނ⎕aȂǂ́uaIԁia֘AgDjvɑ݂oNeA⎕gDɃ_[W^邱ƂȂwIEIȎiɂđ̊O‹ωuEŁinہjvA̍sׂ܂B

AՏŐΏۂƂȂoNeA͎p̕WۂƈقȂARۍ܁A邢͎Ȗ򕨂Ȃǂ̑ϐłȂA‹ωɂΉł鑽lȍ\␶ԂĂ܂BɁAoNeA͓킾łȂَoNeAƂ̃NIZVOɂĐVoNeAWc\ALȐ‹\z܂B

ŁAecbł͂̃oNeA̍\ƐԂloNeAinہEj{Ă܂B

R|PDoNeA̐‹D

ՏIɂ͂܂AoNeA̐‹ƐԂ܂BɁAeoNeA̓ɉā@@DoNeA‹̃KXωzAADoNeAɂČ`ꂽBiofilm (oCItBj̏ȂǁAɂăoNeA𐧈inہEjv܂B

R|QDoNeA̍זEǂj󂷂

oNeAזEǂ̕\w͑̊O‹̕ωuɂƂ炦זȄ튯ɃVOi`BΉw߂dvȋ@\LĂ܂B̂ߍזÊ͋ɂ߂ďvȍ\ɍĂC@\LĂ܂BAecb͉iÑoNeAoɉāu\wiStructural@biologyjv̌PjAoNeAזEǂ̍\IȎ_ɑ΂ĉwIAIȐiiimeNmW[jɂčזEǂj󂵂܂B

yRefferencez

  1. ֌D׋ۍזEǗnECyfQ̑IDHw.XP
    Q50-72. (2013j

R|RDoNeAENIZVOjQ@

oNeÁALȐȂ߂ɏWcōsv܂B̂ߓ̃oNeAԁA邢͑̃oNeAԂŃI[gCf[T[iNIjɂ鉻wIR~jP[ViNIZVOjȂĂ܂B1,2)

łecboNeÃNIZVOjQ邱ɂăoNeA̘AgɂWcUWQ܂BRj

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@@I[gCf[T[Ƃē

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yRefferencesz

  1. Wai-Leung Ng., Bonnie L. Bassler.Bacterial Quorum-Sensing Network Architectures. Annu.Rev.Genet. 2009.43:197-222.

  2. Mami Sato et al. Quorum sensing@of gram-positive bacteria and its inhabitation.Jpn. J. Lactic Acid Bact.;Vol 21 (2), 95-106 (2010)

  3. Kumutha Priya, et al@Anti-Quorum Sensing@Activity@of the Traditional Chinese Herb,Phyllanthus amarus.
    Sensors 2013,13,14558-14569;doi:103390/s13114558

SDecboNeAZp̊Tv

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ǏIȎÂƂ͈ȉ̂Q_łB

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  • QDu_[W󂯂Ă鎕⎕gD񕜁vB

̂Q_ł_[WgD̓oNeAɂĐ̂łAv́uoNeAȂĎÂȂvƂƂɂȂ܂B

ecboNeA͍̓Rۍ܁A]̎ȗp܂wǎgpAoNeAO[v́uvuoNeA\vɁuԁvAȂǂlȂ牻wIAIȎiɂ萧܂B

{Iɂ̓oNeÅO‹̎_fZxAgAZωȂǂ̃XgXƂ炦Đ̂߂ɍזE@\𒲐߂u񐬕`Bnv@\Ȃ߂ɍזEj󂵂܂B

joNeA\̊{m
@@PDBjiProtein Data Bank JapanjAHOMD(Human Oral Micrombiome Database)Ȃǂ
@@f[^x[XoNeÃ^pNA邢͈`q\QƁB

TDecboNeȀǗ

ȉɎaA됫gDoNeAZpɂaPĂ܂B̕aPu׋ۊwIvɊÂoNeAZpɂĉ”\ɂȂĂ܂BaP͕a猟oꂽoNeAɑ΂ĐHwIɍœKȐiIAxȋ@푀ƋZ\ɂĎ܂B

܂AZp͕aIԂ̎gD⍪͑gDɃ_[W^Ȃ悤ɔzĂ܂B̂悤ɂecb̃oNeAZpoNeǍoEŁEinہjAgDیAɐʂ̔܂ł̓ꂽǎÃVXeɂȂĂ܂B

T|PDaP

  • PjǏFaRx@TRˁijAɂ݂JԂAor^݂A|PbgiTjA̓xx

  • QjÌo߁FecboNeAZpiiK@jɂďǏ͏B̂Ƃł̃oNeA𐧈inہEjΕa͉P܂B܂A̕aIȔj̃Jo[͍Ɖuw̖肪Ȃ΃[U[́uʎqwIȋ@\vɂ”\ɂȂ܂B

o|P
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u|P
ioNeAOj

o|Qij

u|Qij

T|QD搫gD̉P

  • PjǏF@RPˁA {̑Oɒɂ݂JԂBȂ

  • QjoNeAȂтɎÌo߁F
    Ǔ̎cۂ͏ʁiu|RjA̒x̃oNeAʂł͒ɂ݂͐ȂBoNeAcۂ̈ꕔɎȗpܑϐۂF߂B܂A̎cۂ͍ǕǏۉ县̐[ɂđBAǓֈړ̂ƍlBʂ̃oNeAoiu|SjAoNeAinہEjiu|TCUj邱ƂɂǏ͏BȂȂΕa͉P܂B

u|R
iO̍Ǔj

@u|S
iۉ县̃oNeAj

u|T
ioNeAj

u|U
iǓoNeAj

Â̏ꍇ͈ʑłȂAOF
׋۔|{iI|n܂ށj {v܂BiSg̖͊qj

UDecboNeǍʔ

oNeAinہEj̔f͈ʑAcm`iobqinveder@jɂĂȂ܂B

oNeA͈̔ʑł͎ƂăoNeA̍זEjԁA^̗LAɂ܂Bcm`ł̓oNeA̎ʂ̃oNeAɂ蔻肵܂B

܂AȖܑϐۂRۍܑϐہA邢͋AJہigXDTȏjȂǂ͈x̐ł͍łBŁA茟̐cیQ̎ނK؂ȐiIэĐv܂B

U|PDʑɂoNeA̔

oNeǍʔ͎ɈʑɂčsȂ܂B͂SiKAoNeAזEǂ̔jԁAcۂȂǂ̏ԂɂĔv܂B

ȉɎ́yu|Vz̓oNeAO̍Ǔɑ݂oNeȀԂłB ʑɂđ푽lȃoNeÅώ@܂B
yu|Wz̓oNeȀԂłB~ƋɃoNeA̍זEǂj󂳂ASɔj󂳂ꂽoNeAł̓vX}ʂɗoĂ܂B

̂悤Ɂy׋ۊwIzɊÂÂƂ́uoNeAsׂ{vłȂAʑɂāuinہjԊmFv̎菇o邱ƂɂĐv܂B

u|V
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u|W
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Pjcm`̒

cm`͕ãoNeA̎ނƎޕʂ̃oNeAʓIɒm邱Ƃł܂B̂߃oNeAOǍlr邱ƂŋqϓIɐʂ𔻒肷邱Ƃ”\ɂȂ܂B

Qjɂcm`̖_

AIȈʑƔrăX^eBbNiÓIjȂcm`Տ̌ɓ邽߂ɂ͈ȉɏqׂ鑽̖_܂B

  1. xȏ̎ȁꍇAL͈͂ɂ킽鎕|PbǵuoNeAvKvɂȂیKpȂƂɂ銳҂܂̌oϓIȕS܂BAP|Pbĝ݂̂cm`A邢͑tɂĎaŜff悤ȎÕj͉ȊwIȗՏƂĖ肪܂B

  2. ÒɃCůώ@łȂ߂Ƀ^C[ɐiIłȂB

  3. ہAۂ̋ʂłȂƁB

  4. oNeÅWcώ@łȂƁB

  5. Ǘł͋ێ킪cm`œłĂoCۂ̂悤ɂPX^Cv݂ꍇA
    PUrqm`ɂ`q͂”\łȂΐmȐsȂƂ͍łB
    S|SDoDۂ͂Pł͂Ȃ

ŁAecb͂PSNԂ̈ʑf[^ƂPONԂ̂cm`̎gpoʂȏǗɌoNeAOǍlrǍʔĂ܂BՏ̐̌ʔ͈ʑōsȂAɋۂ̎ʖ̒ʉKvȏꍇɌcm`ŊmF܂B

U|RDcm`@ɂ锻̏Ǘ

Table-1. ŷcm`ʁz

yǗPz
RQ˒j@a@Qx@oixjA̍̎敔ʁF{QPA|PbgT Oiu|XjƔr(Table-1)̌lɂ݂悤
^[QbgiWIjoNeATێׂ͂ĊSɐĂB

j (Table-1)ɂsDۂ͋LڂĂȂʑɂĐ̗nۂmFρA܂\ڈȊÕoNeA

u|XD
yÖʑz
sDDۂړۂłȂA
̃oNeA݂I

Table-1D
ŷcm`ʁz
ÔsDۂړ
łȂ̑̃oNeA

VDecboNeA̍ŏIړI

ecb̓oNeA@ɂނ⎕a̎ÐтコƋɖdljhƂ”\ɂȂĂ܂B܂ÃoNeAZp̓ɂA҂̐؊JpA邢͍Rۍ܂̓Ȃǂ̒NPÂ߂Ă܂B